1972 Topps set contained 787 cards making it the largest Topps set made at that point in time. The front of each card features a player photo within a colorful frame. The player's team name is across the top in 3D lettering. The reverse provides the player's biographical and statistical information.

There are many sub-series found within the 1972 set including: League Leaders (85-96), Playoffs cards (221-222), World Series (223-230), Boyhood Photos (341-348 & 491-498), Awards and Trophy's cards (621-626), and Traded cards (751-757). "In Action" cards are also found throughout the set.

Important rookie cards found in this set include: Carlton Fisk and Ron Cey.

This set is loaded with hall of famers including: Yaz, Mays, Killebrew, Fisk, Perez, F. Robinson, Gibson, Morgan, Cepeda, Brock, Clemente, Fingers, Palmer, McCovey, Perry, Aaron, Aparicio, Hunter, Jenkins, Carlton, Bench, Jackson, B. Williams, Seaver, Stargell, Williams MG, B. Robinson, Rose, Marichal, Ryan, Kaline, Niekro, Carew, Carlton, Morgan, and Mazeroski.

The high-dollar cards grade as follows:

#49 Mays: Excellent

#79 Fisk & Cooper RC: Very Good

#299 Aaron: Very Good/Excellent

#309 Clemente: Very Good/Excellent

#435 Jackson: Very Good/Excellent

#445 Seaver: Excellent

#559 Rose: Excellent

#595 Ryan: Very Good

#695 Carew: Excellent