The 1978 Topps set contains 726 cards. Each card has a photo of the player with the player's team in script at the bottom of the card. In the upper right corner of the card is a baseball image with the player's position abbreviated. The reverse provides the player's biographical and statistical information.

Sub series in this set include Record Breakers (1-7), League Leaders (201-208), Post Season cards (411-413), and Rookie Prospects (701-711).

Important rookie cards found in this set include: Eddie Murray, Lance Parish, Lou Whitaker, and the multi player card of Paul Molitor and Alan Trammell.

This set is loaded with hall of famers including: Brock, McCovey, Rose, Ryan, Jackson, Niekro, Murray, Yaz, Brett, Carter, Eckersley, Fingers, Palmer, Yount, Fisk, Morgan, Sutton, Schmidt, Seaver, Hunter, Stargell, Winfield, Carlton, Carew, Perry, Bench, Molitor, and Jenkins.

The high-dollar cards grade as follows:

#36 Murray RC: Near Mint

#400 Ryan: Near Mint

#707 Molitor & Trammell RC: Near Mint

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