John Hoffman can refer to:
- John Hoffman (American football) (born 1943), American football defensive end
- John Hoffman (filmmaker) (1904–1980), American montage editor and filmmaker
- John Hoffman (running back) (born 1925), American football running back
- John Hoffman (baseball), Major League Baseball catcher
- John Jay Hoffman, acting Attorney General of New Jersey
- John Robert Hoffman, American actor/screenwriter
- John Thompson Hoffman (1828–1888), Governor of New York, 1869–1872
- John Hoffman (politician), a Minnesota State Senator
